Zafgen Inc(NASDAQ:ZFGN)’s stock gained 7% to $25.84. The company on Dec. 15 announced that the Company has initiated a Phase 2b clinical trial with its lead product candidate, beloranib, in the treatment of patients with both severe obesity and type 2 diabetes.

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The trial is a randomized, double-blind, placebo-controlled design in severely obese adults with a BMI between 30 and 60 kg/m2, and type 2 diabetes. The trial will aim to demonstrate weight loss over a 6 — 12 month period, along with improvements in glycemic control, and is expected to enroll 150 patients at approximately 15 sites across Australia.

Five Prime Therapeutics, Inc. (NASDAQ:FPRX)’s stock climbed 6.63% to $25.89. The company on Dec. 4 announced that the company has initiated dosing in its Phase 1 clinical trial of FPA144, an anti-FGF receptor 2b antibody. FPA144 is designed to inhibit tumor growth by preventing the binding of certain fibroblast growth factors to FGF receptor 2b (FGFR2b) and directly kill tumor cells in a process called antibody-dependent cell-mediated cytotoxicity (ADCC). FPA144 is being developed initially as a monotherapy for refractory gastric cancer, a significant unmet medical need that may warrant an accelerated development and registration path.

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Puma Biotechnology, Inc. (NYSE:PBYI)’s stock jumped 6.06% to $221.30. Law Offices of Howard G. Smith on Dec. 19 announces that it is investigating potential claims on behalf of investors of Puma Biotechnology, Inc. (“Puma” or the “Company”) (PBYI) concerning possible violations of federal securities laws. The investigation focuses on certain statements issued by the Company concerning Puma’s operations and financial prospects.

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The investigation is related to the Company’s December 2, 2014, announcement that its initial New Drug Application (NDA) filing with the U.S. Food and Drug Administration will now be for the early-stage breast cancer indication, and that Puma intends to delay its proposed timeline for filing its NDA until the first quarter of 2016.

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